• Yanagisawa D, Kato T, Taguch H, Shirai N, Hirao K, Sogabe T, Tomiyama T, Gamo K, Hirahara Y, Kitada M, Tooyama I. Keto form of curcumin derivatives strongly binds to Aβ oligomers but not fibril. Biomaterials, in press.
  • Moniruzzaman M, Kadota A, Shiino A, Fujiyoshi A, Ito T, Haidar Syaifullah A, Miyagawa N, Kondo K, Hisamatsu T, Segawa H, Tooyama I, Ueshima H, Miura K; SESSA Research Group. Seven-Day Pedometer-Assessed Step Counts and Brain Volume: A Population-Based Observational Study. J Phys Act Health, in press.
  • Syaifullah AH, Shiino A, Fujiyoshi A, Kadota A, Kondo K, Ito T, Segawa H, Moniruzzaman M, Waki T, Miyagawa N, Tooyama I, Ueshima H, Miura K; SESSA Research Group. Alcohol Drinking and Brain Morphometry in Apparently Healthy Community-Dwelling Japanese Men. Alcohol, 91:57-65, 2021.


  • Tsubaki H, Tooyama I, Walker DG. Thioredoxin-Interacting Protein (TXNIP) with Focus on Brain and Neurodegenerative Diseases. Int J Mol Sci, 21:9357, 2020.
  • Jam FA, Morimune T, Tsukamura A, Tano A, Tanaka Y, Mori Y, Yamamoto T, Nishimura M, Tooyama I, Mori M. Neuroepithelial cell competition triggers loss of cellular juvenescence. Sci Rep, 10:18044, 2020.
  • Ramli NZ, Yahaya MF, Tooyama I, Damanhuri HA. A Mechanistic Evaluation of Antioxidant Nutraceuticals on Their Potential against Age-Associated Neurodegenerative Diseases. Antioxidants (Basel), 9:1019, 2020.
  • Buyandelger U, Walker DG, Taguchi H, Yanagisawa D, Tooyama I. Novel fluorinated derivative of curcumin negatively regulates thioredoxin-interacting protein expression in retinal pigment epithelial and macrophage cells. Biochem Biophys Res Commun, 532:668-674, 2020.
  • Buyandelger U, Walker DG, Yanagisawa D, Morimura T, Tooyama I. Effects of FTMT expression by retinal pigment epithelial cells on features of angiogenesis. Int J Mol Sci, 21:3635, 2020.
  • Fujiyoshi A, Miura K, Ohkubo T, Miyagawa N, Saito Y, Miyazawa I, Shiino A, Kadota A, Kadowaki S, Hisamatsu T, Torii S, Takashima N, Tooyama I, Ueshima H. Proteinuria and Reduced Estimated Glomerular Filtration Rate are Independently Associated with Lower Cognitive Abilities in Apparently Healthy Community-Dwelling Elderly Men in Japan: A Cross-sectional Study. J Epidemiol, 30:244-252, 2020.
  • Kadota Y, Jam FA, Yukiue H, Terakado I, Morimune T, Tano A, Tanaka Y, Akahane S, Fukumura M, Tooyama I, Mori M. Srsf7 Establishes the Juvenile Transcriptome through Age-Dependent Alternative Splicing in Mice. iScience, 23:100929, 2020.
  • Kakiuchi R, Hirayama T, Yanagisawa D, Tooyama I, Nagasawa H. Development of a 19F-MRI probe for the detection of Fe(II) ions in an aqueous system. Org Biomol Chem, 18:5843-5849, 2020.
  • Matsuzaki Tada A, Hamezah HS, Yanagisawa D, Morikawa S, Tooyama I. Neuroprotective effects of casein-derived peptide Met-Lys-Pro (MKP) in a hypertensive model. Front Neurosci, 14:845, 2020.
  • Liu Z, Zaid M, Hisamatsu T, Tanaka S, Fujiyoshi A, Miyagawa N, Ito T, Kadota A, Tooyama I, Miura K, Ueshima H. Elevated fasting blood glucose levels are associated with lower cognitive function, with a threshold in non-diabetic individuals: a population-based study. J Epidemiol, 30:121-127, 2020.
  • Seita Y, Morimura T, Watanabe N, Iwatani C, Tsuchiya H, Nakamura S, Suzuki T, Yanagisawa D, Tsukiyama T, Nakaya M, Okamura E, Muto M, Ema M, Nishimura M, Tooyama I. Generation of Transgenic Cynomolgus Monkeys Overexpressing the Gene for Amyloid-β Precursor Protein. J Alzheimers Dis, 75:45-60, 2020.
  • Siddiquee AT, Kadota A, Fujiyoshi A, Miyagawa N, Saito Y, Suzuki H, Kondo K, Yamauchi H, Ito T, Segawa H, Tooyama I, Miura K, Ueshima H; SESSA Research Group. Alcohol consumption and cognitive function in elderly Japanese men. Alcohol. 85:145-152, 2020.
  • Walker DG, Tang TM, Mendsaikhan A, Tooyama I, Serrano GE, Sue LI, Beach TG, Lue LF. Patterns of Expression of Purinergic Receptor P2RY12, a Putative Marker for Non-Activated Microglia, in Aged and Alzheimer’s Disease Brains. Int J Mol Sci, 21:678, 2020.


  • Bellier JP, Yuan PQ, Mukaisho K, Tooyama I, Taché Y, Kimura H. A Novel Antiserum Against a Predicted Human Peripheral Choline Acetyltransferase (hpChAT) for Labeling Neuronal Structures in Human Colon. Front Neuroanat,13:37, 2019.
  • Hamezah HS, Durani LW, Yanagisawa D, Ibrahim NF, Aizat WM, Makpol S, Wan Ngah WZ, Damanhuri HA, Tooyama I. Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction. J Alzheimers Dis, 72:229-246, 2019.
  • Liu Y, Fujiyoshi A, Arima H, Kadota A, Kadowaki S, Hisamatsu T, Miyazawa I, Kondo K, Tooyama I, Miura K, Ueshima H, SESSA Research Group. Anthropometric Obesity Indices were Stronger than CT-Based Indices in Associations with Carotid Intima-Media Thickness in Japanese Men. J Atheroscler Thromb, 26:1102-114, 2019.
  • Mendsaikhan A, Takeuchi S, Walker DG, Tooyama I. Differences in Gene Expression Profiles and Phenotypes of Differentiated SH-SY5Y Neurons Stably Overexpressing Mitochondrial Ferritin. Front Mol Neurosci, 11:470, 2019.
  • Mendsaikhan A, Tooyama I, Bellier JP, Serrano GE, Sue LI, Lue LF, Beach TG, Walker DG. Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer’s disease and aged brains: increased levels correlate with neuropathology. Acta Neuropathol Commun, 7:215, 2019.
  • Mendsaikhan A, Tooyama I, Walker DG. Microglial Progranulin: Involvement in Alzheimer’s Disease and Neurodegenerative Diseases. Cells, 8:230, 2019.
  • Naruse N, Satooka H, Todo K, Nakanishi A, Taguchi H, Mera Y. Oligomers imaging of amyloid-β1-42 by scanning tunneling microscopy. Jpn J Appl Phys, 58:SIIB30, 2019.
  • Tanaka T, Ono Y, Hikihara N, Yoshida A, Hasumi Y, Higaki S, Nishie T, Tooyama I, Iida K, Hirasawa A, Takada T. Transcriptome analysis revealed Bisphenol A and Nonylphenol affect reproduction. Reprod Toxicol, 88:39-47, 2019.
  • Tano A, Kadota Y, Morimune T, Jam FA, Yukiue H, Bellier JP, Sokoda T, Maruo Y, Tooyama I, Mori M. Juvenility-associated lncRNA Gm14230 maintains cellular juvenescence. J Cell Sci, 132, 2019.
  • Walker DG, Lue LF, Beach TG, Tooyama I. Microglial Phenotyping in Neurodegenerative Disease Brains: Identification of Reactive Microglia with an Antibody to Variant of CD105/Endoglin. Cells, 8:766, 2019.
  • Wan Nasri WN, Makpol S, Mazlan M, Tooyama I, Wan Zurinah Wan Ngah WZ, Damanhuri HA. Tocotrienol Rich Fraction Supplementation Modulate Brain Hippocampal Gene Expression in APPswe/PS1dE9 Alzheimer’s Disease Mouse Model. J Alzheimer Dis, 70:5239-5254, 2019.


  • Durani LW, Hamezah HS, Ibrahim NF, Yanagisawa D, Nasaruddin ML, Mori M, Azizan KA, Damanhuri HA, Makpol S, Wan Ngah WZ, Tooyama I. Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice. J Alzheimers Dis, 64:249-267, 2018.
  • Hamezah HS, Durani LW, Yanagisawa D, Ibrahim NF, Aizat WM, Bellier JP, Makpol S, Ngah WZW, Damanhuri HA, Tooyama I. Proteome profiling in the hippocampus, medial prefrontal cortex, and striatum of aging rat. Exp Gerontol, 111:53-64, 2018.
  • Higaki S, Todo T, Teshima R, Tooyama I, Fujioka Y, Sakai N, Takada T. Cryopreservation of male and female gonial cells by vitrification in the critically endangered cyprinid honmoroko Gnathopogon caerulescens. Fish Physiol Biochem, 44:503-513, 2018.
  • Jam FA, Kadota Y, Mendsaikhan A, Tooyama I, Mori M. Identification of juvenility-associated genes in the mouse hepatocytes and cardiomyocytes. Sci Rep, 8:3132, 2018.
  • Kaneko K, Kubota Y, Nomura K, Hayashimoto H, Chida T, Yoshino N, Wayama M, Ogasawara K, Nakamura Y, Tooyama I, Furuyama K. Establishment of a cell model of X-linked sideroblastic anemia using genome editing. Exp Hematol, 65:57-68.e2, 2018.
  • Liu Z, Kameshima N, Nanjo T, Shiino A, Kato T, Shimizu S, Shimizu T, Tanaka S, Miura K, Tooyama I. Development of a High-Sensitivity Method for the Measurement of Human Nasal Aβ42, Tau, and Phosphorylated Tau. J Alzheimers Dis, 62:737-744, 2018.
  • Seto-Yukimura R, Ogawa E, Hisamatsu T, Torii S, Shiino A, Nozaki K, Fujiyoshi A, Miura K, Nakano Y, Ueshima H. SESSA Research Group. Reduced lung function and cerebral small vessel disease in Japanese men: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). J Atheroscler Thromb, 25:1009-1021, 2018.
  • Takeuchi S, Tooyama I. TRK-fused gene protein localization is prominent in serotonergic and noradrenergic cell groups, and some lower motor neurons in the corticospinal tract of the rat brainstem. Acta Histochem Cytochem, 51:111-118, 2018.
  • Tamaki Y, Shodai A, Morimura T, Hikiami R, Minamiyama S, Ayaki T, Tooyama I, Furukawa Y, Takahashi R, Urushitani M. Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals. Sci Rep, 8:6030, 2018.
  • Yanagisawa D, Hamezah HS, Durani LW, Taguchi H, Tooyama I. Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y5. PLOS ONE, 13:e0208440, 2018.
  • Yanagisawa D, Ibrahim NF, Taguchi H, Morikawa S, Kato T, Hirao K, Shirai N, Sogabe T, Tooyama I. Fluorine-19 magnetic resonance imaging probe for the detection of tau pathology in female rTg4510 mice. J Neurosci Res, 96:841-851, 2018.


  • Bellier JP, Xie Y, Farouk SM, Sakaue Y, Tooyama I, Kimura H. Immunohistochemical and biochemical evidence for the presence of serotonin-containing neurons and nerve fibers in the octopus arm. Brain Struct Funct, 222:3043-3061, 2017.
  • Durani LW, Hamezah HS, Ibrahim NF, Yanagisawa D, Makpol S, Damanhuri HA, Tooyama I. Age-related changes in the metabolic profiles of rat hippocampus, medial prefrontal cortex and striatum. Biochem Biophys Res Commun, 493:1356-1363, 2017.
  • Guan H, Yang H, Yang M, Yanagisawa D, Bellier JP, Mori M, Takahata S, Nonaka T, Zhao S, Tooyama I. Mitochondrial ferritin protects SH-SY5Y cells against H2O2-induced oxidative stress and modulates α-synuclein expression. Exp Neurol, 291:51-61, 2017.
  • Hamezah HS, Durani LW, Ibrahim NF, Yanagisawa D, Kato T, Shiino A, Tanaka S, Damanhuri HA, Ngah WZW, Tooyama I. Volumetric changes in the aging rat brain and its impact on cognitive and locomotor functions. Exp Gerontol, 99:69-79, 2017.
  • Higaki S, Kuwata N, Tanaka K, Tooyama I, Fujioka Y, Sakai N, Takada T. Successful vitrification of whole juvenile testis in the critically en dangered cyprinid honmoroko (Gnathopogon caerulescens). Zygote, 25:652-661, 2017.
  • Higaki S, Shimada M, Kawamoto K, Todo T, Kawasaki T, Tooyama I, Fujioka Y, Sakai N, Takada T. In vitro differentiation of fertile sperm from cryopreserved spermatogonia of the endangered endemic cyprinid honmoroko (Gnathopogon caerulescens). Sci Rep, 7:42852, 2017.
  • Ibrahim NF, Yanagisawa D, Durani LW, Hamezah HS, Damanhuri HD, Wan Ngahb WZ, Tsuji M, Kiuchi Y, Ono K, Tooyama I. Tocotrienol-rich fraction modulates amyloid pathology and improves cognitive function in AβPP/PS1 mice. J Alzheimer Dis, 55:597-612, 2017.
  • Ito T, Tanaka-Mizunio S, Iwashita N, Tooyama I, Shiino A, Miura K, Fukui S. Proton magnetic resonance spectroscopy (1H-MRS) assessment of metabolite status of the anterior cingulate cortex in chronic pain patients and healthy controls. J Pain Res, 10:287-293, 2017.
  • Kitamura Y, Inden M, Kimoto K, Takata K, Yanagisawa D, Hijioka M, Ashihara K, Tooyama I, Shimohama S, Ariga H. Effects of a DJ-1-binding compound on spatial learning and memory impairment in a mouse model of Alzheimer’s disease. J Alzheimer Dis, 55:67-72, 2017.
  • Ogawa T, Irikawa N, Yanagisawa D, Shiino A, Tooyama I, Shimizu T. Taste detection and recognition thresholds in Japanese patients with Alzheimer-type dementia. Auris Nasus Larynx, 44:168-173, 2017.
  • Shiino A, Chen Y-W, Tanigaki K, Yamada A, Vigers P, Watanabe T, Tooyama I, Akiguchi I. Sex-related difference in human white matter volumes studied: Inspection of the corpus callosum and other white matter by VBM. Sci Rep, 7:39818, 2017.
  • Yang M, Yang H, Guan H, Kato T, Mukaisho K, Sugihara H, Ogasawara K, Terada T, Tooyama I. Characterization of a Novel Monoclonal Antibody against Human Mitochondrial Ferritin and its Immunohistochemical Application in Human and Monkey Substantia Nigra. Acta Histochem Cytochem, 50:49-55, 2017.
  • Yanagisawa D, Oda K, Inden M, Morikawa S, Inubushi T, Taniguchi T, Hijioka M, Kitamura Y, Tooyama I. Fluorodopa is a promising fluorine-19 MRI probe for evaluating striatal dopaminergic function in a rat model of Parkinson’s disease. J Neurosci Res, 95:1485-1494, 2017.


  • Abdelalim EM, Bellier JP, Tooyama I: Localization of Brain Natriuretic Peptide Immunoreactivity in Rat Spinal Cord. Front Neuroanat, 10:116, 2016.
  • Inden M, Takata K, Yanagisawa D, Ashihara H, Tooyama I, Shimohama S, Kitamura Y: α4 Nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior. Neurochem Int, 94:74-81, 2016
  • Seita Y, Tsukiyama T, Iwatani C, Tsuchiya H, Matsushita J, Azami T, Okahara J, Nakamura S, Hayashi Y, Hitoshi S, Itoh Y, Imamura T, Nishimura M, Tooyama I, Miyoshi H, Saitou M, Ogasawara K, Sasaki E, Ema M: Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body. Sci Rep, 6:24868, 2016.
  • Sonoda Y, Tooyama I, Mukai H, Maeda K, Akiyama H, Kawamata T: 1S6 kinase phosphorylated at T229 is involved in tau and actin pathologies in Alzheimer’s disease. Neuropathology, 36:325-32, 2016.
  • Tooyama I, Yanagisawa D, Taguchi H, Kato T, Hirao K, Shirai N, Sogabe T, Ibrahim NF, Inubushi T, Morikawa S: Amyloid imaging using fluorine-19 magnetic resonance imaging (19F-MRI). Ageing Res Rev, 30:85-94, 2016.
  • Wang X, Yang H, Yanagisawa D, Bellier JP, Morino K, Zhao S, Liu P, Vigers P, Tooyama I.: Mitochondrial ferritin affects mitochondria by stabilizing HIF-1α in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration. Neurobiol Aging, 47:168-179, 2016.
  • Yang M, Yang H, Guan H, Bellier JP, Zhao S, Tooyama I: Mapping of mitochondrial ferritin in the brainstem of Macaca fascicularis. Neuroscience, 328:92-106, 2016.
  • Zhao L, Yang H, Amano T, Xu M, Qin H, Zheng L, Takahashi A, Zhao S, Tooyama I, Murakami T, Komatsu N: Efficient Delivery of Chlorin e6 into Ovarian Cancer Cell with Octalysine Conjugated Superparamagnetic Iron Oxide Nanoparticle for Effective Photodynamic Therapy. J Mater Chem B, 4:7741-7748, 2016.


  • Yanagisawa D, Taguchi H, Morikawa S, Kato T, Hirao K, Shirai N, Tooyama I: Novel curcumin derivatives as potent inhibitors of amyloid b aggregation. Biochem Biophys Rep 4: 357-368, 2015.
  • Wada Y, Iwasaki Y, Abe T, Wada K, Tooyama I, Ikemura T: CG-containing oligonucleotides and transcription factor-binding motifs are enriched in human pericentric regions. Genes Genet Syst 90: 43-53, 2015.
  • Vipers P, Shiino A, Tooyama I: Diagnosis of amyloid-positive mild cognitive impairment using structural magnetic resonance imaging: The worth of multiple regions of interest. Integr Mol Med 2: 205-213, 2015.
  • Kato T, Konishi Y, Shimohama S, Beach TG, Akatsu H, Tooyama I: Alpha1-chimaerin, a Rac1 GTPase-activating protein, is expressed at reduced mRNA levels in the brain of Alzheimer’s disease patients. Neurosci Lett 591: 19-24, 2015.
  • Yang H, Guan H, Yang M, Liu Z, Takeuchi S, Yanagisawa D, Vincent SR, Zhao S, Tooyama I: Upregulation of Mitochondrial Ferritin by Proinflammatory Cytokines: Implications for a Role in Alzheimer’s Disease. J Alzheimers Dis 45: 797-811, 2015.
  • McClure R, Yanagisawa D, Stec D, Abdollahian D, Koktysh D, Xhillari D, Jaeger R, Stanwood G, Chekmenev E, Tooyama I, Gore JC: Pham W. Inhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer’s disease. J Alzheimers Dis 44: 283-295, 2015.
  • Yanagisawa D, Ibrahim NF, Taguchi H, Morikawa S, Hirao K, Shirai N, Sogabe T, Tooyama I: Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice. Neurobiol Aging 36: 201-210, 2015.
  • Taguchi H, Yanagisawa D, Morikawa S, Hirao K, Shirai N, Tooyama I: Synthesis and tautomerism of curcumin derivatives and related compounds. Aust J Chem 68: 224-229, 2015.


  • Nanjo T, Fukuhara T, Kameshima N, Yanagisawa D, Shimizu S, Shimizu T, Shiino A, Akatsu H, Yamamoto T, Tooyama I: Development of a method to measure Aβ42 in nasal cavity samples and its application in normal human volunteers. J Brain Sci 44: 5-23, 2014.
  • Tamiya G, Makino S, Hayashi M, Abe A, Numakura C, Ueki M, Tanaka A, Ito C, Toshimori K, Ogawa N, Terashima T, Maegawa H, Yanagisawa D, Tooyama I, Tada M, Onodera O, Hayasaka K: A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease. Am J Hum Genet 95: 294-300, 2014.
  • Magdeldin S, Yamamoto T, Tooyama I, Abdelalim EM: New proteomic insights on the role of NPR-A in regulating self-renewal of embryonic stem cells. Stem Cell Rev 10: 561-572, 2014.
  • Miwa M, You G, Tanaka H, Taniguchi S, Fujii T, Kamemura K, Suzaki M, Isono T, Tooyama I, Tanaka M, Srivatanakul P, Viwatthanasittiphong C, Sangrajrang S, Khuhaprema T: Analysis of new biomarkers for cholangiocarcinoma. J Hepatobiliary Pancreat Sci 21: 397-398, 2014.
  • Masuda C, Takeuchi S, Bisem JN, Vincent SR, Tooyama I: Immunohistochemical Localization of an Isoform of TRK-Fused Gene-Like Protein in the Rat Retina. Acta Histochem Cytochem 47: 75-83, 2014.
  • Abdelalim EM, Tooyama I: Knockdown of p53 suppresses Nanog expression in embryonic stem cells. Biochem Biophys Res Commun 443: 652-657, 2014.
  • Yanagisawa D, Taguchi H, Ibrahim NF, Morikawa S, Shiino A, Inubushi T, HIrao K, Shirai N, Sogabe T, Tooyama I: Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain. J Alzheimer’s Dis 39: 617-631 2014..
  • Sakaue Y, Bellier JP, Kimura S, D’Este L, Takeuchi Y, Kimura H. Immunohistochemical localization of two types of choline acetyltransferase in neurons and sensory cells of the octopus arm. Brain Struct Funct. Brain Struct Funct 219: 323-341, 2014. PMID:23354679


  • Higaki S, Koyama Y, Shimada M, Ono Y, Tooyama I, Fujioka Y, Sakai N, Ikeuchi T, Takada T: Response to fish specific reproductive hormones and endocrine disrupting chemicals of a Sertoli cell line expressing endogenous receptors from an endemic cyprinid Gnathopogon caerulescens. Gen Comp Endocr 191: 65-73, 2013.
  • Abdelalim EM, Bellier JP, Tooyama I. Expression of NPR-B in neurons of the dorsal root ganglia of the rat. Peptides 43: 56-61, 2013.
  • Yang H, Yang M, Guan H, Liu Z, Zhao S, Takeuchi S, Yanagisawa D, Tooyama I. Mitochondrial ferritin in neurodegenerative diseases. Folia Histochem Cytobiol. in press. PMID:23916831
  • Takeuchi S, Matsuda W, Tooyama I, Yasuhara O. Kainic acid induces expression of caveolin-1 in activated microglia in rat brain. Folia Histochem Cytobiol. 51(1):25-30, 2013. PMID:23690214
  • Yezdimer EM, Umemoto T, Yamada H, Makino S, Tooyama I. Visualizing Hepatic Copper Release in Long-Evans Cinnamon Rats Using Single-Photon Emission Computed Tomography. Appl Biochem Biotechnol 170: 1138-1150, 2013. PMID:23645415
  • Kameshima N, Yanagisawa D, Tooyama I. β-Amyloid peptide (1-40) in the brain reaches the nasal cavity via a non-blood pathway. Neurosci Res 76: 169-172, 2013. PMID:23603507
  • Abdelalim EM, Bellier JP, Tooyama I. Expression of NPR-B in neurons of the dorsal root ganglia of the rat. Peptides. 43:56-61, 2013. PMID:23454171
  • Makino S, Masuda C, Ando S, Tamiya G, Tooyama I: Generation of a monoclonal antibody specifically recognizing with neuron-specific TATA-box binding protein-associated factor 1 (TAF-1). Antibodies 2: 1-8, 2013.
  • Koga T, Bellier JP, Kimura H, Tooyama I: Immunoreactivity for choline acetyltransferase of peripheral-type (pChAT) in the trigeminal ganglion neurons of the non-human primate Macaca fascicularis. Acta Histochem Cytoc 46: 59-64, 2013.
  • Hanada K, Kishimoto S, Bellier JP, Kimura H. Peripheral choline acetyltransferase in rat skin demonstrated by immunohistochemistry. Cell Tissue Res. 351(3):497-510, 2013. PMID:23250574


  • Bisem NJ, Takeuchi S, Imamura T, Abdelalim EM, Tooyama I. Mapping of FGF1 in the Medulla Oblongata of Macaca fascicularis. Acta Histochem Cytochem. 26;45(6):325-34, 2012. PMID:23378676
  • Kato T, Tamiya G, Koyama S, Nakamura T, Makino S, Arawaka S, Kawanami T, Tooyama I. UBR5 Gene Mutation Is Associated with Familial Adult Myoclonic Epilepsy in a Japanese Family. ISRN Neurol. 2012:508308, 2012. PMID:23029623
  • Casini A, Vaccaro R, D’Este L, Sakaue Y, Bellier JP, Kimura H, Renda TG. Immunolocalization of choline acetyltransferase of common type in the central brain mass of Octopus vulgaris. Eur J Histochem. 56(3):e34, 2012. PMID:23027350
  • Nishimura M, Nakamura S, Kimura N, Liu L, Suzuki T, Tooyama I. Age-related modulation of γ-secretase activity in non-human primate brains. J Neurochem, 123(1):21-8, 2012. PMID:22817324
  • Makino S, Umemoto T, Yamada H, Yezdimer EM, Tooyama I. In vivo detection of copper ions by magnetic resonance imaging using a prion-based contrast agent. Appl Biochem Biotechnol. 168(3):504-18, 2012. PMID:22810201
  • Inden M, Abe M, Minamino H, Takata K, Yoshimoto K, Tooyama I, Kitamura Y. Effect of selective serotonin reuptake inhibitors via 5-HT1A receptors on L-DOPA-induced rotational behavior in a hemiparkinsonian rat model. J Pharmacol Sci. 119(1):10-9, 2012. PMID:22510520
  • Takeuchi S, Masuda C, Maebayashi H, Tooyama I. Immunohistochemical Mapping of TRK-Fused Gene Products in the Rat Brainstem. Acta Histochem Cytochem.45(1):57-64, 2012. PMID:22489105
  • Maebayashi H, Takeuchi S, Masuda C, Makino S, Fukui K, Kimura H, Tooyama I. Expression and Localization of TRK-Fused Gene Products in the Rat Brain and Retina. Acta Histochem Cytochem. 29;45(1):15-23, 2012. PMID: 22489101
  • Abdelalim EM, Tooyama I. The p53 inhibitor, pifithrin-α, suppresses self-renewal of embryonic stem cells. Biochem Biophys Res Commun. 420(3):605-10, 2012. PMID:22445757
  • Kameshima N, Nanjou T, Fukuhara T, Yanagisawa D, Tooyama I. Correlation of Aβ deposition in the nasal cavity with the formation of senile plaques in the brain of a transgenic mouse model of Alzheimer’s disease. Neurosci Lett.;513(2):166-9, 2012. PMID:22343315
  • Park D, Lee HJ, Joo SS, Bae DK, Yang G, Yang YH, Lim I, Matsuo A, Tooyama I, Kim YB, Kim SU. Human neural stem cells over-expressing choline acetyltransferase restore cognition in rat model of cognitive dysfunction. Exp Neurol.;234(2):521-6, 2012. PMID:22245157
  • Akatsu H, Hori A, Yamamoto T, Yoshida M, Mimuro M, Hashizume Y, Tooyama I, Yezdimer EM. Transition metal abnormalities in progressive dementias. Biometals. 25(2):337-50, 2012. PMID:22080191
  • Park D, Joo SS, Kim TK, Lee SH, Kang H, Lee HJ, Lim I, Matsuo A, Tooyama I, Kim YB, Kim SU. Human neural stem cells overexpressing choline acetyltransferase restore cognitive function of kainic acid-induced learning and memory deficit animals. Cell Transplant. 21(1):365-71, 2012. PMID:21929870
  • Abdelalim EM, Tooyama I. NPR-C protects embryonic stem cells from apoptosis by regulating p53 levels. Stem Cells Dev. 21(8):1264-71, 2012. PMID:21846177
  • Shiino A, Akiguchi I, Watanabe T, Shirakashi Y, Nozaki K, Tooyama I, Inubushi T. Morphometric characterization of Binswanger’s disease: comparison with Alzheimer’s disease. Eur J Radiol. 81(9):2375-9, 2012. PMID:21708443


  • Wang L, Yang H, Zhao S, Sato H, Konishi Y, Beach TG, Abdelalim EM, Bisem NJ, Tooyama I. Expression and localization of mitochondrial ferritin mRNA in Alzheimer’s disease cerebral cortex. PLoS One.6(7):e22325, 2011. PMID:21799823
  • Sako W, Morigaki R, Kaji R, Tooyama I, Okita S, Kitazato K, Nagahiro S, Graybiel AM, Goto S. Identification and localization of a neuron-specific isoform of TAF1 in rat brain: implications for neuropathology of DYT3 dystonia. Neuroscience. 189:100-7, 2011. PMID:21616129
  • Yanagisawa D, Amatsubo T, Morikawa S, Taguchi H, Urushitani M, Shirai N, Hirao K, Shiino A, Inubushi T, Tooyama I. In vivo detection of amyloid β deposition using ¹⁹F magnetic resonance imaging with a ¹⁹F-containing curcumin derivative in a mouse model of Alzheimer’s disease. Neuroscience. 184:120-7, 2011. PMID:21497641
  • Abdelalim EM, Tooyama I. Mapping of NPR-B immunoreactivity in the brainstem of Macaca fascicularis. Brain Struct Funct. 216(4):387-402, 2011. PMID:21455797
  • Abdelalim EM, Tooyama I. NPR-A regulates self-renewal and pluripotency of embryonic stem cells. Cell Death Dis. 2:e127, 2011. PMID:21390061
  • Bellier JP, Kimura H. Peripheral type of choline acetyltransferase: biological and evolutionary implications for novel mechanisms in cholinergic system. J Chem Neuroanat. 42(4):225-35, 2012. PMID:21382474
  • Morimoto K, Horio J, Satoh H, Sue L, Beach T, Arita S, Tooyama I, Konishi Y. Expression profiles of cytokines in the brains of Alzheimer’s disease (AD) patients compared to the brains of non-demented patients with and without increasing AD pathology. J Alzheimers Dis. 25(1):59-76, 2011. PMID:21368376
  • Yanagisawa D, Taguchi H, Yamamoto A, Shirai N, Hirao K, Tooyama I. Curcuminoid binds to amyloid-β1-42 oligomer and fibril. J Alzheimers Dis. 24 Suppl 2:33-42, 2011. PMID:21335654
  • D’Este L, Casini A, Kimura S, Bellier JP, Ito E, Kimura H, Renda TG. Immunohistochemical demonstration of cholinergic structures in central ganglia of the slug (Limax maximus, Limax valentianus). Neurochem Int.;58(5):605-11, 2011. PMID:21315127
  • Matsuo A, Bellier JP, Nishimura M, Yasuhara O, Saito N, Kimura H. Nuclear choline acetyltransferase activates transcription of a high-affinity choline transporter. J Biol Chem. 286(7):5836-45, 2011. PMID:21163949
  • Casini A, Vivacqua G, Pontieri FE, Kimura H, Bellier JP, D’Este L, Renda TG. Choline acetyltransferase of the common type immunoreactivity in the rat brain following different heroin treatments: a pilot study. J Chem Neuroanat. 41(2):111-21, 2011. PMID:21184823


  • Nakahara H, Konishi Y, Beach TG, Yamada N, Makino S, Tooyama I. Infiltration of T lymphocytes and expression of icam-1 in the hippocampus of patients with hippocampal sclerosis. Acta Histochem Cytochem. 43(6):157-62, 2010. PMID:21245982
  • Amatsubo T, Yanagisawa D, Morikawa S, Taguchi H, Tooyama I. Amyloid imaging using high-field magnetic resonance. Magn Reson Med Sci. 9(3):95-9, 2010. PMID:20885081
  • Takeuchi S, Fujiwara N, Ido A, Oono M, Takeuchi Y, Tateno M, Suzuki K, Takahashi R, Tooyama I, Taniguchi N, Julien JP, Urushitani M. Induction of protective immunity by vaccination with wild-type apo superoxide dismutase 1 in mutant SOD1 transgenic mice. J Neuropathol Exp Neurol. 69(10):1044-56, 2010. PMID:20838241
  • Wang L, Sato H, Zhao S, Tooyama I. Deposition of lactoferrin in fibrillar-type senile plaques in the brains of transgenic mouse models of Alzheimer’s disease. Neurosci Lett. 481(3):164-7, 2010. PMID:20599473
  • Yanagisawa D, Shirai N, Amatsubo T, Taguchi H, Hirao K, Urushitani M, Morikawa S, Inubushi T, Kato M, Kato F, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Wada Y, Wada KN, Yamamoto A, Tooyama I. Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer’s disease. Biomaterials. 31(14):4179-85, 2010. PMID:20181392
  • Abdelalim EM, Tooyama I. NPR-C is expressed in the cholinergic and dopaminergic amacrine cells in the rat retina. Peptides. 31(1):180-3, 2010. PMID:19878700
  • Urushitani M, Sato T, Bamba H, Hisa Y, Tooyama I. Synergistic effect between proteasome and autophagosome in the clearance of polyubiquitinated TDP-43. J Neurosci Res. 88(4):784-97, 2010. PMID:19798749


  • Yanagida T, Tsushima J, Kitamura Y, Yanagisawa D, Takata K, Shibaike T, Yamamoto A, Taniguchi T, Yasui H, Taira T, Morikawa S, Inubushi T, Tooyama I, Ariga H. Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury. Oxid Med Cell Longev.2(1):36-42, 2009. PMID:20046643
  • Sato T, Takeuchi S, Saito A, Ding W, Bamba H, Matsuura H, Hisa Y, Tooyama I, Urushitani M. Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons. Neuroscience. 164(4):1565-78, 2009. PMID:19782731
  • Oda K, Makino S, Masuda C, Yoshiki T, Kitamura Y, Takata K, Yanagisawa D, Taniguchi T, Tooyama I. The mRNA distribution of C7orf24, a gamma-glutamyl cyclotransferase, in rat tissues. J Histochem Cytochem. 57(12):1121-6, 2009. PMID:19687470
  • Abdelalim EM, Tooyama I. BNP signaling is crucial for embryonic stem cell proliferation. PLoS One. 4(4):e5341, 2009. PMID:19399180
  • An L, Sato H, Konishi Y, Walker DG, Beach TG, Rogers J, Tooyama I. Expression and localization of lactotransferrin messenger RNA in the cortex of Alzheimer’s disease. Neurosci Lett. 452(3):277-80, 2009. PMID:19348738
  • Saito A, Sato T, Okano H, Toyoda K, Bamba H, Kimura S, Bellier JP, Matsuo A, Kimura H, Hisa Y, Tooyama I. Axotomy alters alternative splicing of choline acetyltransferase in the rat dorsal motor nucleus of the vagus nerve. J Comp Neurol. 513(2):237-48, 2009. PMID: 19137611
  • Amatsubo T, Morikawa S, Inubushi T, Urushitani M, Taguchi H, Shirai N, Hirao K, Kato M, Morino K, Kimura H, Nakano I, Yoshida C, Okada T, Sano M, Tooyama I. Trifluoromethoxy-benzylated ligands improve amyloid detection in the brain using (19)F magnetic resonance imaging. Neurosci Res. 63(1):76-81, 2009. PMID:18996420


  • Abdelalim EM, Masuda C, Bellier JP, Saito A, Yamamoto S, Mori N, Tooyama I. Distribution of natriuretic peptide receptor-C immunoreactivity in the rat brainstem and its relationship to cholinergic and catecholaminergic neurons. Neuroscience. 155(1):192-202, 2008. PMID:18571869
  • D’Este L, Kimura S, Casini A, Matsuo A, Bellier JP, Kimura H, Renda TG. First visualization of cholinergic cells and fibers by immunohistochemistry for choline acetyltransferase of the common type in the optic lobe and peduncle complex of Octopus vulgaris. J Comp Neurol. 509(6):566-79, 2008. PMID: 18543295
  • Urushitani M, Ezzi SA, Matsuo A, Tooyama I, Julien JP. The endoplasmic reticulum-Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS. FASEB J. 22(7):2476-87, 2008. PMID:18337461
  • Abdelalim EM, Masuda C, Tooyama I. Expression of natriuretic peptide-activated guanylate cyclases by cholinergic and dopaminergic amacrine cells of the rat retina. Peptides.29(4):622-8, 2008. PMID:18192083
  • Wilberding A, Morimoto K, Satoh H, Harano K, Harano T, Arita S, Tooyama I, Konishi Y. Multiple cytokines are involved in the early events leading to the Alzheimer’s disease pathology. Tottori Rinsho Kagaku Kenkyukai Shi. 1(2):359-373, 2008. PMID: 22586434
  • Yanagisawa D, Kitamura Y, Inden M, Takata K, Taniguchi T, Morikawa S, Morita M, Inubushi T, Tooyama I, Taira T, Iguchi-Ariga SM, Akaike A, Ariga H. DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. J Cereb Blood Flow Metab. 28(3):563-78, 2008. PMID:17882163