業績

主な業績

* corresponding author; # equally contributed author

  1. Fujioka, Y.#, Kawai, K.#, Endo, K., Ishibashi, M., Iwade, N., Tuerde, D., Kaibuchi, K., Yamashita, T., Yamanaka A., Katsuno, M., Watanabe, H., Sobue, G. and Ishigaki, S*. (2024) Stress-impaired reward pathway promotes distinct feeding behavior patterns. Front. Neurosci. 18:1349366. doi: 10.3389/fnins.2024.1349366

  2. Aldoghachi, A.F., Yanagisawa, D.#, Pahrudin Arrozi, A., Abu Bakar, Z.H., Taguchi, H., Ishigaki, S., Morino, K., and Tooyama, I#. (2023). Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes. Biochem. Biophys. Res. Commun. 694, 149392. 10.1016/j.bbrc.2023.149392.

  3. Yanagisawa, D. #, Kato, T. #, Taguchi, H., Shirai, N., Hirao, K., Sogabe, T., Tomiyama, T., Gamo, K., Hirahara, Y., Kitada, M., and Tooyama, I. Keto form of curcumin derivatives strongly binds to Aβ oligomers but not fibril. Biomaterials, 270: 120686, 2021.

  4. Ishigaki, S.*, Riku, Y., Fujioka, Y., Endo, K., Iwade, N., Kawai, K., Ishibashi, M., Yokoi, S., Katsuno, M., Watanabe, H., Mori, K., Akagi, A., Yokota, O., Terada, S., Kawakami, I., Suzuki, N., Warita, H., Aoki, M., Yoshida, M., and Sobue, G., Aberrant interaction between FUS and SFPQ in neurons in a wide range of FTLD spectrum diseases. Brain, 143: 2398-2405, 2020.

  5. Ishigaki, S.* and Sobue, G., Importance of Functional Loss of FUS in FTLD/ALS. Front Mol Biosci, 2018. 5: 44.

  6. Endo, K., Ishigaki, S.*, Masamizu, Y., Fujioka, Y., Watakabe, A., Yamamori, T., Hatanaka, N., Nambu, A., Okado, H., Katsuno, M., Watanabe, H., Matsuzaki, M., and Sobue, G., Silencing of FUS in the common marmoset (Callithrix jacchus) brain via stereotaxic injection of an adeno-associated virus encoding shRNA. Neurosci Res, 130: 56-64, 2018.

  7. Ishigaki, S.*,#, Fujioka, Y.#, Okada, Y., Riku, Y., Udagawa, T., Honda, D., Yokoi, S., Endo, K., Ikenaka, K., Takagi, S., Iguchi, Y., Sahara, N., Takashima, A., Okano, H., Yoshida, M., Warita, H., Aoki, M., Watanabe, H., Okado, H., Katsuno, M., and Sobue, G., Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes. Cell Rep, 18: 1118-1131, 2017.

  8. Yokoi, S., Udagawa, T., Fujioka, Y., Honda, D., Okado, H., Watanabe, H., Katsuno, M., Ishigaki, S.*, and Sobue, G., 3’UTR Length-Dependent Control of SynGAP Isoform alpha2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function. Cell Rep, 20: 3071-3084, 2017.

  9. Udagawa, T.#, Fujioka, Y.#, Tanaka, M., Honda, D., Yokoi, S., Riku, Y., Ibi, D., Nagai, T., Yamada, K., Watanabe, H., Katsuno, M., Inada, T., Ohno, K., Sokabe, M., Okado, H., Ishigaki, S.*, and Sobue, G., FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization. Nat Commun, 6: 7098, 2015.

  10. Fujioka, Y.., Ishigaki, S.*, Masuda, A., Iguchi, Y., Udagawa, T., Watanabe, H., Katsuno, M., Ohno, K., and Sobue, G., FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD. Sci Rep, 3: 2388, 2013.

  11. Ishigaki, S.#, Masuda, A.#, Fujioka, Y., Iguchi, Y., Katsuno, M., Shibata, A., Urano, F., Sobue, G., and Ohno, K., Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions. Sci Rep, 2: 529, 2012.