業績

主な業績

* corresponding author; # equally contributed author

  1. Iwata-Endo K＃, Sahashi K#, Kawai K#, Fujioka Y, Okada Y, Watanabe E, Iwade N, Ishibashi M, Mohammad M, Aldoghachi AF, Tuerde D, Fujiwara T, Hirai S, Okado H, Katsuno M, Watanabe H, Kanamitsu K, Neya M, Ishigaki S* and Sobue G. Correcting Tau Isoform Ratios with a Long-Acting Antisense Oligonucleotide Alleviates 4R-Tauopathy Phenotypes. Mol Ther Nucleic Acids. In press. https://doi.org/10.1016/j.omtn.2025.102503

  2. Fujioka, Y.#, Kawai, K.#, Endo, K., Ishibashi, M., Iwade, N., Tuerde, D., Kaibuchi, K., Yamashita, T., Yamanaka A., Katsuno, M., Watanabe, H., Sobue, G. and Ishigaki, S*. (2024) Stress-impaired reward pathway promotes distinct feeding behavior patterns. Front. Neurosci. 18:1349366. doi: 10.3389/fnins.2024.1349366

  3. Aldoghachi, A.F., Yanagisawa, D.#, Pahrudin Arrozi, A., Abu Bakar, Z.H., Taguchi, H., Ishigaki, S., Morino, K., and Tooyama, I#. (2023). Fluorinated curcumin derivative (Shiga-Y6) modulates the level of thioredoxin-interacting protein (TXNIP) in a mouse model of diabetes. Biochem. Biophys. Res. Commun. 694, 149392. 10.1016/j.bbrc.2023.149392.

  4. Yanagisawa, D. #, Kato, T. #, Taguchi, H., Shirai, N., Hirao, K., Sogabe, T., Tomiyama, T., Gamo, K., Hirahara, Y., Kitada, M., and Tooyama, I. Keto form of curcumin derivatives strongly binds to Aβ oligomers but not fibril. Biomaterials, 270: 120686, 2021.

  5. Ishigaki, S.*, Riku, Y., Fujioka, Y., Endo, K., Iwade, N., Kawai, K., Ishibashi, M., Yokoi, S., Katsuno, M., Watanabe, H., Mori, K., Akagi, A., Yokota, O., Terada, S., Kawakami, I., Suzuki, N., Warita, H., Aoki, M., Yoshida, M., and Sobue, G., Aberrant interaction between FUS and SFPQ in neurons in a wide range of FTLD spectrum diseases. Brain, 143: 2398-2405, 2020.

  6. Ishigaki, S.* and Sobue, G., Importance of Functional Loss of FUS in FTLD/ALS. Front Mol Biosci, 2018. 5: 44.

  7. Endo, K., Ishigaki, S.*, Masamizu, Y., Fujioka, Y., Watakabe, A., Yamamori, T., Hatanaka, N., Nambu, A., Okado, H., Katsuno, M., Watanabe, H., Matsuzaki, M., and Sobue, G., Silencing of FUS in the common marmoset (Callithrix jacchus) brain via stereotaxic injection of an adeno-associated virus encoding shRNA. Neurosci Res, 130: 56-64, 2018.

  8. Ishigaki, S.*,#, Fujioka, Y.#, Okada, Y., Riku, Y., Udagawa, T., Honda, D., Yokoi, S., Endo, K., Ikenaka, K., Takagi, S., Iguchi, Y., Sahara, N., Takashima, A., Okano, H., Yoshida, M., Warita, H., Aoki, M., Watanabe, H., Okado, H., Katsuno, M., and Sobue, G., Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes. Cell Rep, 18: 1118-1131, 2017.

  9. Yokoi, S., Udagawa, T., Fujioka, Y., Honda, D., Okado, H., Watanabe, H., Katsuno, M., Ishigaki, S.*, and Sobue, G., 3’UTR Length-Dependent Control of SynGAP Isoform alpha2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function. Cell Rep, 20: 3071-3084, 2017.

  10. Udagawa, T.#, Fujioka, Y.#, Tanaka, M., Honda, D., Yokoi, S., Riku, Y., Ibi, D., Nagai, T., Yamada, K., Watanabe, H., Katsuno, M., Inada, T., Ohno, K., Sokabe, M., Okado, H., Ishigaki, S.*, and Sobue, G., FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization. Nat Commun, 6: 7098, 2015.

  11. Fujioka, Y.., Ishigaki, S.*, Masuda, A., Iguchi, Y., Udagawa, T., Watanabe, H., Katsuno, M., Ohno, K., and Sobue, G., FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD. Sci Rep, 3: 2388, 2013.

  12. Ishigaki, S.#, Masuda, A.#, Fujioka, Y., Iguchi, Y., Katsuno, M., Shibata, A., Urano, F., Sobue, G., and Ohno, K., Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions. Sci Rep, 2: 529, 2012.