業績

2022年

* corresponding author; # equally contributed author

  1. Riku Y, Yoshida M, Iwasaki Y, Sobue G, Katsuno M, Ishigaki S. TDP-43 Proteinopathy and Tauopathy: Do They Have Pathomechanistic Links? Int J Mol Sci. 2022 Dec 12;23(24):15755. doi: 10.3390/ijms232415755.

  2. Yokoi S, Ito T, Sahashi K, Nakatochi M, Nakamura R, Tohnai G, Fujioka Y, Ishigaki S, Udagawa T, Izumi Y, Morita M, Kano O, Oda M, Sone T, Okano H, Atsuta N, Katsuno M, Okada Y, Sobue G. The SYNGAP1 3’UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK.  J Neurosci. 2022 Online ahead of print.

  3. Riku, Y., Iwasaki, Y., Ishigaki, S., Akagi, A., Hasegawa, M., Nishioka, K., Li, Y., Riku, M., Ikeuchi, T., Fujioka, Y., Miyahara, H., Sone, J., Hattori, N., Yoshida, M., Katsuno, M., and Sobue, G. Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration. Brain, 2022. Online ahead of print.

  4. Tsujikawa, K., Hamanaka, K., Riku, Y., Hattori, Y., Hara, N., Iguchi, Y., Ishigaki, S., Hashizume, A., Miyatake, S., Mitsuhashi, S., Miyazaki, Y., Kataoka, M., Jiayi, L., Yasui, K., Kuru, S., Koike, H., Kobayashi, K., Sahara, N., Ozaki, N., Yoshida, M., Kakita, A., Saito, Y., Iwasaki, Y., Miyashita, A., Iwatsubo, T.; Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI), Ikeuchi, T.; Japanese Longitudinal Biomarker Study in PSP and CBD (JALPAC) Consortium, Miyata, T., Sobue, G., Matsumoto, N., Sahashi, K., and Katsuno, M. Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology. Sci Adv. 2022 May 27;8(21):eabm5029. Epub 2022 May 25.

  5. Takata, K., Kimura, H., Yanagisawa, D., Harada, K., Nishimura, K., Kitamura, Y., Shimohama, S., and Tooyama, I. Nicotinic acetylcholine receptors and microglia as therapeutic and imaging targets in Alzheimer’s disease. Molecules, 27: 2780, 2022.

  6. Matsuzaki Tada A., Hamezah H.S., Pahrudin Arrozi A., Abu Bakar Z.H., Yanagisawa D.*, and Tooyama I*. Pharmaceutical potential of casein-derived tripeptide Met-Lys-Pro: improvement in cognitive impairments and suppression of inflammation in APP/PS1 mice. J Alzheimers Dis, Online ahead of print.

  7. Abu Bakar, Z.H., Bellier, J.P., Yanagisawa, D., Kato, T., Mukaisho, K., and Tooyama, I. LC3/FtMt colocalization patterns reveal the progression of FtMt accumulation in nigral neurons of patients with progressive supranuclear palsy. Int J Mol Sci, 23: 537, 2022.