業績

2016年以前

* corresponding author; # equally contributed author

  1. Watanabe, H., Atsuta, N., Hirakawa, A., Nakamura, R., Nakatochi, M., Ishigaki, S., Iida, A., Ikegawa, S., Kubo, M., Yokoi, D., Watanabe, H., Ito, M., Katsuno, M., Izumi, Y., Morita, M., Kanai, K., Taniguchi, A., Aiba, I., Abe, K., Mizoguchi, K., Oda, M., Kano, O., Okamoto, K., Kuwabara, S., Hasegawa, K., Imai, T., Kawata, A., Aoki, M., Tsuji, S., Nakashima, K., Kaji, R., and Sobue, G., A rapid functional decline type of amyotrophic lateral sclerosis is linked to low expression of TTN. J Neurol Neurosurg Psychiatry, 87: 851-8, 2016.

  2. Inden, M., Takata, K., Yanagisawa, D., Ashihara, E., Tooyama, I., Shimohama, S., and Kitamura, Y. α4 Nicotinic acetylcholine receptor modulated by galantamine on nigrostriatal terminals regulates dopamine receptor-mediated rotational behavior. Neurochem Int, 94: 74–81, 2016.

  3. Masuda, M., Senda, J., Watanabe, H., Epifanio, B., Tanaka, Y., Imai, K., Riku, Y., Li, Y., Nakamura, R., Ito, M., Ishigaki, S., Atsuta, N., Koike, H., Katsuno, M., Hattori, N., Naganawa, S., and Sobue, G., Involvement of the caudate nucleus head and its networks in sporadic amyotrophic lateral sclerosis-frontotemporal dementia continuum. Amyotroph Lateral Scler Frontotemporal Degener, 17: 571-579, 2016.

  4. Nakashima, H., Ohkawara, B., Ishigaki, S., Fukudome, T., Ito, K., Tsushima, M., Konishi, H., Okuno, T., Yoshimura, T., Ito, M., Masuda, A., Sobue, G., Kiyama, H., Ishiguro, N., and Ohno, K., R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5. Sci Rep, 6: 28512, 2016.

  5. Noda, T., Iijima, M., Noda, S., Maeshima, S., Nakanishi, H., Kimura, S., Koike, H., Ishigaki, S., Iguchi, Y., Katsuno, M., and Sobue, G., Gene Expression Profile of Inflammatory Myopathy with Malignancy is Similar to that of Dermatomyositis rather than Polymyositis. Intern Med, 55: 2571-80, 2016.

  6. Riku, Y., Watanabe, H., Yoshida, M., Mimuro, M., Iwasaki, Y., Masuda, M., Ishigaki, S., Katsuno, M., and Sobue, G., Marked Involvement of the Striatal Efferent System in TAR DNA-Binding Protein 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis. J Neuropathol Exp Neurol, 75: 801-811, 2016.

  7. Tooyama, I., Yanagisawa, D., Taguchi, H., Kato, T., Hirao, K., Shirai, N., Sogabe, T., Ibrahim, N.F., Inubushi, T., and Morikawa, S. Amyloid imaging using fluorine-19 magnetic resonance imaging (19F-MRI). Ageing Res Rev, 30: 85–94, 2016.

  8. Wang, X., Yang, H., Yanagisawa, D., Bellier, J.-P., Morino, K., Zhao, S., Liu, P., Vigers, P., and Tooyama, I. Mitochondrial ferritin affects mitochondria by stabilizing HIF-1α in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration. Neurobiol Aging, 47: 168–179, 2016.

  9. Udagawa, T.#, Fujioka, Y.#, Tanaka, M., Honda, D., Yokoi, S., Riku, Y., Ibi, D., Nagai, T., Yamada, K., Watanabe, H., Katsuno, M., Inada, T., Ohno, K., Sokabe, M., Okado, H., Ishigaki, S.*, and Sobue, G., FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization. Nat Commun, 6: 7098, 2015.

  10. Foyez, T., Takeda-Uchimura, Y., Ishigaki, S., Narentuya, Zhang, Z., Sobue, G., Kadomatsu, K., and Uchimura, K., Microglial keratan sulfate epitope elicits in central nervous tissues of transgenic model mice and patients with amyotrophic lateral sclerosis. Am J Pathol, 185: 3053-65, 2015.

  11. Hikiji, T., Norisada, J., Hirata, Y., Okuda, K., Nagasawa, H., Ishigaki, S., Sobue, G., Kiuchi, K., and Oh-hashi, K., A highly sensitive assay of IRE1 activity using the small luciferase NanoLuc: Evaluation of ALS-related genetic and pathological factors. Biochem Biophys Res Commun, 463: 881-7, 2015.

  12. Masuda, A., Takeda, J., Okuno, T., Okamoto, T., Ohkawara, B., Ito, M., Ishigaki, S., Sobue, G., and Ohno, K., Position-specific binding of FUS to nascent RNA regulates mRNA length. Genes Dev, 29: 1045-57, 2015.

  13. Oh-Hashi, K., Sone, A., Hikiji, T., Hirata, Y., Vitiello, M., Fedele, M., Ishigaki, S., Sobue, G., and Kiuchi, K., Transcriptional and post-transcriptional regulation of transmembrane protein 132A. Mol Cell Biochem, 405: 291-9, 2015.

  14. McClure, R., Yanagisawa, D., Stec, D., Abdollahian, D., Koktysh, D., Xhillari, D., Jaeger, R., Stanwood, G., Chekmenev, E., and Tooyama, I., Gore, J.C., Pham, W. Inhalable curcumin: offering the potential for translation to imaging and treatment of Alzheimer’s disease. J Alzheimers Dis, 44: 283–295, 2015.

  15. Taguchi, H., Yanagisawa, D., Morikawa, S., Hirao, K., Shirai, N., and Tooyama I. Synthesis and tautomerism of curcumin derivatives and related compounds. Aust J Chem, 68: 224–229, 2015.

  16. Yang, H., Guan, H., Yang, M., Liu, Z., Takeuchi, S., Yanagisawa, D., Vincent, S.R., Zhao, S., and Tooyama, I. Up-regulation of mitochondrial ferritin by proinflammatory cytokines: Implications for a role in Alzheimer’s disease. J Alzheimers Dis, 45: 797–811, 2015.

  17. Yanagisawa, D., Ibrahim, N.F., Taguchi, H., Morikawa, S., Hirao, K., Shirai, N., Sogabe, T., and Tooyama, I. Curcumin derivative with the substitution at C-4 position, but not curcumin, is effective against amyloid pathology in APP/PS1 mice. Neurobiol Aging, 36: 201–210, 2015.

  18. Yanagisawa, D., Taguchi, H., Morikawa, S., Kato, T., Hirao, K., Shirai, N., and Tooyama, I. Novel curcumin derivatives as potent inhibitors of amyloid β aggregation. Biochem Biophys Rep, 4: 357–368, 2015.

  19. Nanjo, T., Fukuhara, T., Kameshima, N., Yanagisawa, D., Shimizu, S., Shimizu, T., Shiino, A., Akatsu, H., Yamamoto, T., and Tooyama, I. Development of a method to measure Aβ42 in nasal cavity samples and its application in normal human volunteers. J Brain Sci, 44: 5–23, 2014.

  20. Riku, Y., Watanabe, H., Yoshida, M., Tatsumi, S., Mimuro, M., Iwasaki, Y., Katsuno, M., Iguchi, Y., Masuda, M., Senda, J., Ishigaki, S., Udagawa, T., and Sobue, G., Lower motor neuron involvement in TAR DNA-binding protein of 43 kDa-related frontotemporal lobar degeneration and amyotrophic lateral sclerosis. JAMA Neurol, 71: 172-9, 2014.

  21. Tamiya G, G., Makino, S., Hayashi, M., Abe, A., Numakura, C., Ueki, M., Tanaka, A., Ito, C., Toshimori, K., Ogawa, N., Terashima, T., Maegawa, H., Yanagisawa, D., Tooyama, I., Tada, M., Onodera, O., and Hayasaka, K. A mutation of COX6A1 causes a recessive axonal or mixed form of Charcot-Marie-Tooth disease. Am J Hum Genet, 95: 294–300, 2014.

  22. Yanagisawa, D., Taguchi, H., Ibrahim, N.F., Morikawa, S., Shiino, A., Inubushi, T., Hirao, K., Shirai, N., Sogabe, T., and Tooyama, I. Preferred features of a fluorine-19 MRI probe for amyloid detection in the brain. J Alzheimers Dis, 39: 617–631, 2014.

  23. Fujioka, Y.., Ishigaki, S.*, Masuda, A., Iguchi, Y., Udagawa, T., Watanabe, H., Katsuno, M., Ohno, K., and Sobue, G., FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD. Sci Rep, 3: 2388, 2013.

  24. Honda, D., Ishigaki, S.*, Iguchi, Y., Fujioka, Y., Udagawa, T., Masuda, A., Ohno, K., Katsuno, M., and Sobue, G., The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons. FEBS Open Bio, 4: 1-10, 2013.

  25. Iguchi, Y., Katsuno, M., Ikenaka, K., Ishigaki, S., and Sobue, G., Amyotrophic lateral sclerosis: an update on recent genetic insights. J Neurol, 260: 2917-27, 2013.

  26. Iguchi, Y., Katsuno, M., Niwa, J., Takagi, S., Ishigaki, S., Ikenaka, K., Kawai, K., Watanabe, H., Yamanaka, K., Takahashi, R., Misawa, H., Sasaki, S., Tanaka, F., and Sobue, G., Loss of TDP-43 causes age-dependent progressive motor neuron degeneration. Brain, 136: 1371-82, 2013.

  27. Kameshima, N., Yanagisawa, D., and Tooyama, I.β-Amyloid peptide (1-40) in the brain reaches the nasal cavity via a non-blood pathway. Neurosci Res, 76: 169–172, 2013.

  28. Kanekura, K.# Ishigaki, S.#, Merksamer, P.I., Papa, F.R., and Urano, F., Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells. Lab Invest, 93: 1254-8, 2013.

  29. Kondo, N., Katsuno, M., Adachi, H., Minamiyama, M., Doi, H., Matsumoto, S., Miyazaki, Y., Iida, M., Tohnai, G., Nakatsuji, H., Ishigaki, S., Fujioka, Y., Watanabe, H., Tanaka, F., Nakai, A., and Sobue, G., Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration. Nat Commun, 4: 1405, 2013.

  30. Koyano, F., Okatsu, K., Ishigaki, S., Fujioka, Y., Kimura, M., Sobue, G., Tanaka, K., and Matsuda, N., The principal PINK1 and Parkin cellular events triggered in response to dissipation of mitochondrial membrane potential occur in primary neurons. Genes Cells, 18: 672-81, 2013.

  31. Sama, R.R., Ward, C.L., Kaushansky, L.J., Lemay, N., Ishigaki, S., Urano, F., and Bosco, D.A., FUS/TLS assembles into stress granules and is a prosurvival factor during hyperosmolar stress. J Cell Physiol, 228: 2222-31, 2013.

  32. Takagi, S., Iguchi, Y., Katsuno, M., Ishigaki, S., Ikenaka, K., Fujioka, Y., Honda, D., Niwa, J., Tanaka, F., Watanabe, H., Adachi, H., and Sobue, G., RNP2 of RNA recognition motif 1 plays a central role in the aberrant modification of TDP-43. PLoS One, 8: e66966, 2013.

  33. Yang, H., Yang, M., Guan, H., Liu, Z., Zhao, S., Takeuchi, S., Yanagisawa, D., and Tooyama, I. Mitochondrial ferritin in neurodegenerative diseases. Neurosci Res, 77: 1–7, 2013.

  34. Iguchi, Y., Katsuno, M., Takagi, S., Ishigaki, S., Niwa, J., Hasegawa, M., Tanaka, F., and Sobue, G., Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies. Neurobiol Dis, 45: 862-70, 2012.

  35. Ikenaka, K., Katsuno, M., Kawai, K., Ishigaki, S., Tanaka, F., and Sobue, G., Disruption of axonal transport in motor neuron diseases. Int J Mol Sci, 13: 1225-38, 2012.

  36. Ishigaki, S.#, Masuda, A.#, Fujioka, Y., Iguchi, Y., Katsuno, M., Shibata, A., Urano, F., Sobue, G., and Ohno, K., Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions. Sci Rep, 2: 529, 2012.

  37. Kameshima, N., Nanjou, T., Fukuhara, T., Yanagisawa, D., and Tooyama, I. Correlation of Aβ deposition in the nasal cavity with the formation of senile plaques in the brain of a transgenic mouse model of Alzheimer’s disease. Neurosci Lett, 513: 166–169, 2012.

  38. Katsumata, R., Ishigaki, S., Katsuno, M., Kawai, K., Sone, J., Huang, Z., Adachi, H., Tanaka, F., Urano, F., and Sobue, G., c-Abl inhibition delays motor neuron degeneration in the G93A mouse, an animal model of amyotrophic lateral sclerosis. PLoS One, 7: e46185, 2012.

  39. Minamiyama, M., Katsuno, M., Adachi, H., Doi, H., Kondo, N., Iida, M., Ishigaki, S., Fujioka, Y., Matsumoto, S., Miyazaki, Y., Tanaka, F., Kurihara, H., and Sobue, G., Naratriptan mitigates CGRP1-associated motor neuron degeneration caused by an expanded polyglutamine repeat tract. Nat Med, 18: p. 1531-8, 2012.

  40. Oslowski, C.M., Hara, T., O’Sullivan-Murphy, B., Kanekura, K., Lu, S., Hara, M., Ishigaki, S., Zhu, L.J., Hayashi, E., Hui, S.T., Greiner, D., Kaufman, R.J., Bortell, R., and Urano, F., Thioredoxin-interacting protein mediates ER stress-induced beta cell death through initiation of the inflammasome. Cell Metab, 16: 265-73, 2012.

  41. Yanagisawa, D. #, Amatsubo, T. #, Morikawa, S., Taguchi, H., Urushitani, M., Shirai, N., Hirao, K., Shiino, A., Inubushi, T., and Tooyama, I. In vivo detection of amyloid β deposition using 19F magnetic resonance imaging with a 19F-containing curcumin derivative in a mouse model of Alzheimer’s disease. Neuroscience, 184: 120–127, 2011.

  42. Yanagisawa, D., Taguchi, H., Yamamoto, A., Shirai, N., Hirao, K., and Tooyama, I. Curcuminoid binds to amyloid β (1-42) oligomer and fibril. J Alzheimers Dis, 24 Supplement 2: 33–42, 2011.

  43. Amatsubo, T., Yanagisawa, D., Morikawa, S., Taguchi, H., and Tooyama, I. Amyloid imaging using high-field magnetic resonance. Magnet Resonance Med Sci, 9: 95–99, 2010.

  44. Sone, J., Niwa, J., Kawai, K., Ishigaki, S., Yamada, S., Adachi, H., Katsuno, M., Tanaka, F., Doyu, M., and Sobue, G., Dorfin ameliorates phenotypes in a transgenic mouse model of amyotrophic lateral sclerosis. J Neurosci Res, 88: 123-35, 2010.

  45. Fonseca, S.G., Ishigaki, S., Oslowski, C.M., Lu, S., Lipson, K.L., Ghosh, R., Hayashi, E., Ishihara, H., Oka, Y., Permutt, M.A., and Urano, F., Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells. J Clin Invest, 120: 744-55, 2010.

  46. Ishigaki, S.*, Fonseca, S.G., Oslowski, C.M., Jurczyk, A., Shearstone, J.R., Zhu, L.J., Permutt, M.A., Greiner, D.L., Bortell, R., and Urano, F., AATF mediates an antiapoptotic effect of the unfolded protein response through transcriptional regulation of AKT1. Cell Death Differ, 17: 774-86, 2010.

  47. Yanagisawa, D., Shirai, N., Amatsubo, T., Taguchi, H., Hirao, K., Urushitani, M., Morikawa, S., Inubushi, T., Kato, M., Kato, F., Morino, K., Kimura, H., Nakano, I., Yoshida, C., Okada, T., Sano, M., Wada, Y., Wada, K.-n., Yamamoto, A., and Tooyama, I. Relationship between the tautomeric structures of curcumin derivatives and their Aβ-binding activities in the context of therapies for Alzheimer’s disease. Biomaterials, 31: 4179–4185, 2010.

  48. Kakiuchi, C., Ishigaki, S., Oslowski, C.M., Fonseca, S.G., Kato, T., and Urano, F., Valproate, a mood stabilizer, induces WFS1 expression and modulates its interaction with ER stress protein GRP94. PLoS One, 4: e4134, 2009.

  49. Oda, K., Makino, S., Masuda, C., Yoshiki, T., Kitamura, Y., Takata, K., Yanagisawa, D., Taniguchi, T., and Tooyama, I. The mRNA distribution of C7orf24, a gamma-glutamyl cyclotransferase, in rat tissues. J Histochem Cytochem, 57: 1121–1126, 2009.

  50. Yanagida, T., Tsushima, J., Kitamura, Y., Yanagisawa, D., Takata, K., Shibaike, T., Yamamoto, A., Taniguchi, T., Yasui, H., Taira, T., Morikawa, S., Inubushi, T., Tooyama, I., and Ariga, H. Oxidative stress induction of DJ-1 protein in reactive astrocytes scavenges free radicals and reduces cell injury. Oxid Med Cell Longev, 2: 36–42, 2009.

  51. Yanagisawa, D., Kitamura, Y., Inden, M., Takata, K., Taniguchi, T., Morikawa, S., Morita, M., Inubushi, T., Tooyama, I., Taira, T., Iguchi-Ariga, S.M.M., Akaike, A., and Ariga, H. DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. J Cereb Blood Flow Metab, 28: 563–578, 2008.

  52. Yanagisawa, D., Kitamura, Y., Takata, K., Hide, I., Nakata, Y., and Taniguchi, T. Possible involvement of P2X7 receptor activation in microglial neuroprotection against focal cerebral ischemia in rats. Biol Pharm Bull, 31: 1121–1130, 2008.

  53. Niwa, J., Yamada, S., Ishigaki, S., Sone, J., Takahashi, M., Katsuno, M., Tanaka, F., Doyu, M., and Sobue, G., Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1. J Biol Chem, 282: 28087-95, 2007.

  54. Jiang, Y.M., Yamamoto, M., Tanaka, F., Ishigaki, S., Katsuno, M., Adachi, H., Niwa, J., Doyu, M., Yoshida, M., Hashizume, Y., and Sobue, G., Gene expressions specifically detected in motor neurons (dynactin 1, early growth response 3, acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to pathologic markers in sporadic amyotrophic lateral sclerosis. J Neuropathol Exp Neurol, 66: 617-27, 2007.

  55. Ishigaki, S., Niwa, J., Yamada, S., Takahashi, M., Ito, T., Sone, J., Doyu, M., Urano, F., and Sobue, G., Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity. Neurobiol Dis, 25: 331-41, 2007.

  56. Takata, K., Kitamura, Y., Yanagisawa, D., Morikawa, S., Morita, M., Inubushi, T., Tsuchiya, D., Chishiro, S., Saeki, M., Taniguchi, T., Shimohama, S., and Tooyama, I. Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats. FEBS Letters, 581: 575–578, 2007.

  57. Yamada, S., Niwa, J., Ishigaki, S., Takahashi, M., Ito, T., Sone, J., Doyu, M., and Sobue, G., Archaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells. J Biol Chem, 281: 23842-51, 2006.

  58. Lipson, K.L., Fonseca, S.G., Ishigaki, S., Nguyen, L.X., Foss, E., Bortell, R., Rossini, A.A., and Urano, F., Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metab, 4: 245-54, 2006.

  59. Tanaka, F., Niwa, J., Ishigaki, S., Katsuno, M., Waza, M., Yamamoto, M., Doyu, M., and Sobue, G., Gene expression profiling toward understanding of ALS pathogenesis. Ann N Y Acad Sci, 1086: 1-10, 2006.

  60. Inden, M., Taira, T., Kitamura, Y., Yanagida, T., Tsuchiya, D., Takata, K., Yanagisawa, D., Nishimura, K., Taniguchi, T., Kiso, Y., Yoshimoto, K., Agatsuma, T., Koide-Yoshida, S., Iguchi-Ariga, S.M.M., Shimohama, S., and Ariga, H. PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson’s disease rat model. Neurobiol Dis, 24: 144–158, 2006.

  61. Yanagisawa, D., Qi, M., Kim, D.-h., Kitamura, Y., Inden, M., Tsuchiya, D., Takata, K., Taniguchi, T., Yoshimoto, K., Shimohama, S., Akaike, A., Sumi, S., and Inoue, K. Improvement of focal ischemia-induced rat dopaminergic dysfunction by striatal transplantation of mouse embryonic stem cells. Neurosci Lett, 407: 74–79, 2006.

  62. Jiang, Y.M., Yamamoto, M., Kobayashi, Y., Yoshihara, T., Liang, Y., Terao, S., Takeuchi, H., Ishigaki, S., Katsuno, M., Adachi, H., Niwa, J., Tanaka, F., Doyu, M., Yoshida, M., Hashizume, Y., and Sobue, G., Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis. Ann Neurol, 57: 236-51, 2005.

  63. Inden, M., Kim, D.-H., Qi, M., Kitamura, Y., Yanagisawa, D., Nishimura, K., Tsuchiya, D., Takata, K., Hayashi, K., Taniguchi, T., Yoshimoto, K., Shimohama, S., Sumi, S., and Inoue, K. Transplantation of mouse embryonic stem cell-derived neurons into the striatum, subthalamic nucleus and substantia nigra, and behavioral recovery in hemiparkinsonian rats. Neurosci Lett, 387: 151–156, 2005.

  64. Inden, M., Kitamura, Y., Kondo, J.-I., Hayashi, K., Yanagida, T., Takata, K., Tsuchiya, D., Yanagisawa, D., Nishimura, K., Taniguchi, T., Shimohama, S., Sugimoto, H., and Akaike, A. Serofendic acid prevents 6-hydroxydopamine-induced nigral neurodegeneration and drug-induced rotational asymmetry in hemiparkinsonian rats. J Neurochem, 95: 950–961, 2005.

  65. Kitamura, Y., Yanagisawa, D., Inden, M., Takata, K., Tsuchiya, D., Kawasaki, T., Taniguchi, T., and Shimohama, S. Recovery of ischemia-induced behavioral dysfunction by intracerebroventricular injection of microglia. J Pharmacol Sci, 97: 289–293, 2005.

  66. Takeuchi, H., Niwa, J., Hishikawa, N., Ishigaki, S., Tanaka, F., Doyu, M., and Sobue, G., Dorfin prevents cell death by reducing mitochondrial localizing mutant superoxide dismutase 1 in a neuronal cell model of familial amyotrophic lateral sclerosis. J Neurochem, 89: 64-72, 2004.

  67. Ishigaki, S., Hishikawa, N., Niwa, J., Iemura, S., Natsume, T., Hori, S., Kakizuka, A., Tanaka, K., and Sobue, G., Physical and functional interaction between Dorfin and Valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders. J Biol Chem, 279: 51376-85, 2004.

  68. Kitamura, Y., Takata, K., Inden, M., Tsuchiya, D., Yanagisawa, D., Nakata, J., and Taniguchi, T. Intracerebroventricular injection of microglia protects against focal brain ischemia. J Pharmacol Sci, 94: 203–206, 2004.

  69. Ito, T., Niwa, J., Hishikawa, N., Ishigaki, S., Doyu, M., and Sobue, G., Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1. J Biol Chem, 278: 29106-14, 2003.

  70. Hishikawa, N., Niwa, J., Doyu, M., Ito, T., Ishigaki, S., Hashizume, Y., and Sobue, G., Dorfin localizes to the ubiquitylated inclusions in Parkinson’s disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis. Am J Pathol, 163: 609-19, 2003.

  71. Ando, Y., Liang, Y., Ishigaki, S., Niwa, J., Jiang, Y., Kobayashi, Y., Yamamoto, M., Doyu, M., and Sobue, G., Caspase-1 and -3 mRNAs are differentially upregulated in motor neurons and glial cells in mutant SOD1 transgenic mouse spinal cord: a study using laser microdissection and real-time RT-PCR. Neurochem Res, 28: 839-46, 2003.

  72. Yoshihara, T., Ishigaki, S., Yamamoto, M., Liang, Y., Niwa, J., Takeuchi, H., Doyu, M., and Sobue, G., Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. J Neurochem, 80: 158-67, 2002.

  73. Takeuchi, H., Kobayashi, Y., Ishigaki, S., Doyu, M., and Sobue, G., Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-dependent cell death in a cellular model of familial amyotrophic lateral sclerosis. J Biol Chem, 277: 50966-72, 2002.

  74. Niwa, J., Ishigaki, S., Hishikawa, N., Yamamoto, M., Doyu, M., Murata, S., Tanaka, K., Taniguchi, N., and Sobue, G., Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity. J Biol Chem, 277: 36793-8, 2002.

  75. Ishigaki, S., Niwa, J., Ando, Y., Yoshihara, T., Sawada, K., Doyu, M., Yamamoto, M., Kato, K., Yotsumoto, Y., and Sobue, G., Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords–screening by molecular indexing and subsequent cDNA microarray analysis. FEBS Lett, 531: 354-8, 2002.

  76. Ishigaki, S., Liang, Y., Yamamoto, M., Niwa, J., Ando, Y., Yoshihara, T., Takeuchi, H., Doyu, M., and Sobue, G., X-Linked inhibitor of apoptosis protein is involved in mutant SOD1-mediated neuronal degeneration. J Neurochem, 82: 576-84, 2002.

  77. Niwa, J., Ishigaki, S., Doyu, M., Suzuki, T., Tanaka, K., and Sobue, G., A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity. Biochem Biophys Res Commun, 281: 706-13, 2001.

  78. Yasui, K., Ishigaki, S., Koike, H., Ieda, T., Yoshida, M., Hashizume, Y., Watanabe, K., and Sobue, G., Correlation of magnetic resonance imaging findings and histopathology of lesion distribution of spinal cord sarcoidosis at post-mortem. Neuropathol Appl Neurobiol, 26: 481-7, 2000.

  79. Ishigaki, S., Niwa, J., Yoshihara, T., Mitsuma, N., Doyu, M., and Sobue, G., Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells. Biochem Biophys Res Commun, 279: 526-33, 2000.

  80. Ishigaki, S., Toi, M., Ueno, T., Matsumoto, H., Muta, M., Koike, M., and Seiki, M., Significance of membrane type 1 matrix metalloproteinase expression in breast cancer. Jpn J Cancer Res, 90: 516-22, 1999.

  81. Toi, M., Ishigaki, S., and Tominaga, T., Metalloproteinases and tissue inhibitors of metalloproteinases. Breast Cancer Res Treat, 52: 113-24, 1998.